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As such, WM is widely involved in the achievement of complex tasks such as learning, decision making, and reasoning.

Critically, decline in WM is a major factor in cognitive impairment that accompanies healthy aging.

Methods: We devised a computerized setup to record and assess the maternal care provided by wild-type or heterozygous BDNF val66met (hets) dams on offspring which were screened for individual anxiety-like behavior at the light dark, peripheral markers of IR and central glucocorticoid function in adulthood, and subsequently assessed for memory function in later age.

Maternal care was assessed on the basis of previously employed ethological parameters by analyzing in and out of the nest caring and self-maintenance behaviors.

Background: Working memory (WM) is the ability to perform mental operations on information that is stored in a flexible, limited capacity buffer.

Through the interface between long-term memories and moment-to-moment information available in the environment, WM allows humans to carry out successful goal-directed behaviors.

Results: We find that offspring receiving low quality maternal care in the early life show peripheral IR in adulthood as suggested by increased levels of insulin, glucose and tryglicerides in comparison with offspring that received high quality maternal care.

Methods: We conducted a 12-month double-blinded, placebo-controlled trial in older adults to assess the efficacy of combination memantine and escitalopram therapy compared to escitalopram and placebo for the treatment of depression (Clinical NCT01902004).Sponsorship Statement: Publication of this supplement is sponsored by the ACNP.Individual contributor disclosures may be found within the abstracts.Furthermore, low nurtured mice showed cognitive impairments in contextual memory at the Y maze in midlife, suggesting dementia-like symptoms, which were not apparent before.Conclusions: These findings suggest a role for ELA in the form of poor maternal care in increasing the likelihood to development of peripheral IR, altered central glucocorticoid function and corresponding anxiety states in adulthood, and that these factors may encode lifelong susceptibility to pathophysiological aging.

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